Chargers vs. Arizona Cardinals: How to watch, prediction and betting odds

If the Chargers struggled to contain Denver’s rookie quarterback Bo Nix, Kyler Murray easily could turn into a nightmare.

The Arizona Cardinals’ dynamic dual-threat quarterback is the top concern of the Chargers’ top-ranked defense for Monday’s prime-time matchup in State Farm Stadium as the Cardinals (2-4) are trying to shake off a rut of three losses in four weeks.

A 50-yard touchdown run from Murray provided a highlight in the Cardinals’ lone victory in the last month as he spurred Arizona to a thrilling 24-23 win in San Francisco in Week 5.

Along with running back James Conner, Murray leads an offense that’s tied for second in the league with 5.3 yards rushing per carry. Conner ranks eighth in the NFL in rushing with 403 yards, immediately behind Chargers running back J.K. Dobbins, who has 438 yards in one fewer game.

After giving up 61 yards rushing to Nix last week, the Chargers (3-2) will be short-handed on defense with outside linebacker Joey Bosa (hip) doubtful and defensive backs Asante Samuel Jr. (shoulder, on injured reserve) and Deane Leonard (hamstring) out.

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Injuries in the secondary could again force rookies Cam Hart and Tarheeb Still into larger roles after they both started against the Broncos.

Still, a fifth-round draft pick who has started two straight games at nickel is eagerly anticipating his NFL prime-time debut.

“Everybody in the country is watching,� Still said, “but that’s just a bigger stage to do bigger things.�

Chargers: DB Deane Leonard (hamstring, out); OLB Joey Bosa (hip, doubtful); TE Hayden Hurst (groin, doubtful); WR Quentin Johnston (ankle, doubtful); CB Ja’Sir Taylor (fibula, questionable); CB Kristian Fulton (hamstring, questionable); WR D.J. Chark Jr. (groin, questionable); WR Derius Davis (hamstring, questionable); WR Simi Fehoko (shoulder/groin, questionable); WR Ladd McConkey (hip, questionable).

Cardinals: LB Owen Pappoe (hip, out); DL Darius Robinson (calf, out); RB Trey Benson (illness, questionable); OL Christian Jones (ankle, questionable); DL Roy Lopez (ankle, questionable); CB Sean Murphy-Bunting (neck, questionable); LB Kyzir White (knee, questionable); CB Garrett Williams (groin, questionable).

The Chargers and Arizona Cardinals will play at 6 p.m. PDT on Monday at State Farm Stadium in Glendale, Ariz. The game will air on KCOP (Channel 13) in Southern California and will be available on ESPN+. In Southern California, fans can listen to the game on the radio at 98.7 FM and 105.5 FM.

Thuc Nhi Nguyen’s pick: With Justin Herbert healthy again, the Chargers are only beginning to tap into their potential on offense. They have a favorable matchup against a porous Arizona defense that has a versatile play-maker in safety Budda Baker, but ranks 29th in yards rushing allowed per game. Chargers 24, Cardinals 13

Sam Farmer’s pick: The Chargers put together three great quarters on defense before a fourth-quarter letdown last weekend. Cardinals have been great within their division but nowhere else. This figures to be a close one. Chargers 24, Cardinals 20