Exposure to air pollution linked to higher coronavirus-related death rates

Americans in communities with higher smog levels are at greater risk of dying from COVID-19, according to a new study that suggests the health damage from the novel coronavirus has been worsened by long-term exposure to air pollution.

Scientists at Harvard T.H. Chan School of Public Health analyzed data on more than 3,000 U.S. counties to link small increases in long-term exposure to fine-particle pollution to substantially higher death rates from the coronavirus.

Researchers calculated long-term average levels of fine-particle pollution — lung-damaging soot also known as PM2.5 — from 2000 to 2016 and compared it to the more than 7,000 COVID-19 deaths that had occurred through April 4. They found that an increase of only one microgram per cubic meter of PM2.5 was associated with a 15% rise in the coronavirus death rate.

Francesca Dominici, a professor of biostatistics at Harvard and coauthor of the study, said her team fast-tracked its research in response to the surge in coronavirus deaths out of a “moral obligation� to help inform the response to the health crisis. The scientists released their manuscript before publication, while it undergoes peer review, and made public their data and code, hoping that it can be used worldwide to help focus research and prevent deaths.

Dominici said it was, to her knowledge, the first nationwide study to quantify the relationship between coronavirus death rates and exposure to one of the most widespread types of air pollution. She said she wanted to get the information out as soon as possible because it suggests health officials should pay closer attention to limiting the damage in the worst-polluted communities, including many in California, where people’s health has long suffered from poor air quality.

“These are the places where we should really be careful about social distancing measures and they should be even more enforced,� she said. “If COVID infects you, because you have lungs that are already inflamed because you’ve been breathing polluted air for so long, you might experience a worse health outcome than somewhere else.�

The findings come as the Trump administration plows ahead with major environmental rollbacks even as the coronavirus crisis widens. In recent weeks the U.S. Environmental Protection Agency finalized a major rollback of auto emission standards and announced a sweeping decision to suspend enforcement on a range of health and environmental protections in response to the pandemic.

The Harvard scientists said their results “underscore the importance of continuing to enforce existing air pollution regulations to protect human health both during and after the COVID-19 crisis,� adding that “we anticipate a failure to do so can potentially increase the COVID-19 death toll and hospitalizations, further burdening our healthcare system and drawing resources away from COVID-19 patients.�

Environmentalists and health groups said the study provides stark new evidence of the shortsightedness of weakening or delaying pollution safeguards during the pandemic.

“These findings illustrate that far too many Americans are facing multiple threats to their lung health at once, and when taken together, these different threats to lung health impacts can amplify each other,� American Lung Assn. President Harold Wimmer said in a statement.�We cannot afford to delay cleanup of dangerous air pollution. In fact, it is more important than ever.�

Dominici said her research was sparked by observations that many of the same underlying health problems that increase risk of death from COVID-19, such as heart and lung disease, are also made worse by long-term exposure to air pollution. The researchers adjusted for other factors such as income, obesity and smoking that are also likely to increase risk of death.

The research team is automating its analysis to rerun as the pandemic continues, Dominici said, “unfortunately, as we expect the number of deaths to increase.�

Many scientists have suspected that bad air makes people more susceptible to the coronavirus, based on past research into similar viruses that showed it increases people’s risk of contracting pneumonia and of developing more severe symptoms once they have it. Research into the SARS coronavirus outbreak in 2003 found that infected patients from regions with higher air pollution were 84% more likely to die than those in less polluted areas.

The results from the Harvard study are “consistent with the limited data that we have on this family of viruses: that it could be a potentially important determinant of severity of the infection,� said Frank Gilliland, a professor of preventive medicine at USC who was not involved in the research. “We know that PM2.5 increases a spectrum of respiratory diseases ... so it wouldn’t be too surprising that it actually has adverse effects on COVID-19.�

Gilliland emphasized the study should be interpreted with caution because it looked at data at the county, rather than the individual level, so the higher death rates in more polluted areas could also reflect other population characteristics unrelated to air pollution.

“This is very early research, but it does suggest that people who live in high-pollution areas really need to follow the recommendations for social distancing and do as much as they can to avoid getting infected and infecting other people,� Gilliland said.

Michael Jerrett, a professor of environmental health science at the UCLA Fielding School of Public Health who read the study, called it “a good first look� and “a potentially important finding given that so many Americans and people all over the world live in areas with unhealthy pollution levels.�

“The main concern is with the likely huge uncertainty with the findings due to undercounting of the deaths in many places,� Jerrett said. “Because testing capacity is still very low, many deaths that were likely due to COVID have not been counted as such, and this has the potential to bias the results.�

The study, he added, “merits replication in other areas, particularly in places like Germany and South Korea, where they have been testing a lot more than we have here.�